Thermo Fisher Scientific Laminin gamma-2 Monoclonal Antibody (CL2980)
Laminin gamma-2 단백질을 특이적으로 인식하는 Thermo Fisher Scientific의 단클론 항체(CL2980). Western blot, IHC, ICC/IF 등 다양한 응용에 적합하며, 인간 시료에 반응. 고순도 Protein A 정제, 1 mg/mL 농도로 PBS/glycerol 완충액에 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 2–10 µg/mL |
| ChIP assay (ChIP) | – |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CL2980 |
| Immunogen | Recombinant protein corresponding to Human Laminin gamma-2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2637261 |
Product Specific Information
- Immunogen sequence:
NAGVTIQDTL NTLDGLLHLM DQPLSVDEEG LVLLEQKLSR AKTQINSQLR PMMSELEERA RQQRGHLHLL ETSIDGILAD VKNLEN - Highest antigen sequence identity to orthologs: Mouse 83%, Rat 79%
- Binds to an epitope within peptide sequence IQDTLNTLDGLLHLM (determined by overlapping synthetic peptides)
Target Information
Laminins are extracellular matrix glycoproteins and major noncollagenous components of basement membranes. They play key roles in cell adhesion, differentiation, migration, signaling, neurite outgrowth, and metastasis. Laminins are composed of three non-identical chains (alpha, beta, and gamma), forming heterotrimeric structures (e.g., laminin 1 = α1β1γ1).
The Laminin gamma-2 chain is highly homologous to gamma-1 but lacks domain VI and has shorter domains V–III. It is expressed in epithelial tissues such as skin, lung, and kidney, forming part of Laminin 5 (kalinin), which anchors epithelial cells to basement membranes. Mutations in the gamma-2 gene are associated with junctional epidermolysis bullosa, a blistering skin disorder. Two transcript variants of gamma-2 exist due to alternative splicing, with differential expression in embryonic tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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