Thermo Fisher Scientific Hopx Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1.0-2.0 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

5 µg/mL

-

ELISA (ELISA)

Assay-Dependent

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

HOPX antibody for a 16 amino acid peptide near the amino terminus of human HOPX. The immunogen is within the first 50 amino acids of HOPX. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:HOPX,uniProtId:Q9BPY8-1,ncbiNodeId:9606,antigenRange:1|1-50,antigenLength:73,antigenImageFileName:PA5-72855_HOPX_Q9BPY8-1_Rabbit.svg,antigenImageFileNamePDP:PA5-72855_HOPX_Q9BPY8-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2718709

Target Information

HOPX is an atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. HOPX acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. HOPX prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. HOPX overexpression causes cardiac hypertrophy and may act as a tumor suppressor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.