Thermo Fisher Scientific SIGLEC8 Polyclonal Antibody
Human SIGLEC8 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC(P) 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SIGLEC8 (aa 385–499). Recombinant protein control fragment: Product #RP-90052 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856185 |
Product Specific Information
Immunogen sequence:
RSCRKKSARP AAGVGDTGME DAKAIRGSAS QGPLTESWKD GNPLKKPPPA VAPSSGEEGE LHYATLSFHK VKPQDPQGQE ATDSEYSEIK IHKRETAETQ ACLRNHNPSS KEVRG
Target Information
SIGLEC8 is a putative adhesion molecule that mediates sialic acid-dependent binding to cells. It preferentially binds to α2,3-linked sialic acid and also binds to α2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
SIGLEC8 is expressed specifically on eosinophils. The protein contains one cytoplasmic motif referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM), which is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. The SIGLEC8 gene belongs to the immunoglobulin superfamily.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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