Thermo Fisher Scientific LPHN1 Polyclonal Antibody
LPHN1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB 및 IHC에 적합합니다. 인간, 마우스, 랫트 반응성이 있으며, 동결건조 형태로 제공됩니다. 연구용으로만 사용되며 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
- 카탈로그번호
- OSL00013W-100UL
- 판매단위
- pk
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Thermo Fisher Scientific LPHN1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from 1t extracellular domain of human Latrophilin-1 (LPHN1) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity: LPHN1.
Target Information
Adgrl1 (Latrophilin-1) is a calcium-independent receptor with high affinity for alpha-latrotoxin, a neurotoxin from black widow spider venom that triggers massive exocytosis from neurons and neuroendocrine cells.
Adgrl1 acts as a receptor for TENM2, mediating synaptic cell-cell contact and postsynaptic specialization, and may regulate exocytosis.
It encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR), functioning in both cell adhesion and signal transduction.
Proteolytic cleavage within a cysteine-rich GPS domain results in two subunits that remain non-covalently associated at the cell membrane.
Adgrl1 recruits alpha-latrotoxin to the synapse plasma membrane.
Alternative splicing produces multiple isoforms.
Diseases associated with ADGRL1 include Dermatophytosis and Retinal Degeneration, Late-Onset, Autosomal Dominant.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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