Thermo Fisher Scientific Uromodulin Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• In direct ELISAs and Western blots, less than 5% cross-reactivity with recombinant human Uromodulin is observed.
• Reconstitute at 0.2 mg/mL in sterile PBS.
• Endotoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.

Target Information

This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinositol-anchored counterpart located on the luminal surface of the loop of Henle.
Uromodulin may act as an inhibitor of calcium crystallization in renal fluids and provide defense against urinary tract infections caused by uropathogenic bacteria.
Defects in this gene are associated with autosomal dominant renal disorders such as medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure.
Two major transcript variants encoding the same isoform have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.