Thermo Fisher Scientific CDNF Polyclonal Antibody
CDNF 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot 및 동결 절편 면역조직화학에 적합합니다. 마우스 유래 항원으로 제작되었으며, 항원 친화 크로마토그래피로 정제되었습니다. 파킨슨병 연구 등 도파민 신경세포 관련 연구에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Immunohistochemistry (Frozen) (IHC (F)) | 5–15 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant mouse CDNF (Leu27–Leu187) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No preservative |
| Storage Conditions | –20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2606900 |
Product Specific Information
- In direct ELISAs, approximately 30% cross-reactivity with recombinant human CDNF is observed.
- Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
The conserved dopamine neurotrophic factor (CDNF) is a neurotrophic factor for dopaminergic neurons and is highly homologous to the mesencephalic astrocyte-derived neurotrophic factor (MANF).
CDNF is expressed at higher levels in tissues such as heart, skeletal muscle, and testes than in the brain.
Similar to the glial cell line-derived neurotrophic factor (GDNF), CDNF can prevent 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons in a rat model of Parkinson’s disease.
Furthermore, CDNF has been shown to restore dopaminergic function and prevent neuronal degeneration in the substantia nigra, suggesting potential therapeutic value for Parkinson’s disease.
At least two isoforms of CDNF are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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