Thermo Fisher Scientific Sarcomeric Actinin Alpha 2/ACTN2 Recombinant Rabbit Monoclonal Antibody (ACTN2/7040R)
Recombinant Rabbit Monoclonal Antibody for ACTN2 detection. Suitable for IHC (Paraffin, PFA fixed) and peptide array applications. High specificity for human alpha-actinin 2. Supplied as liquid, 1 mg/mL, purified by Protein A/G, preservative-free.
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- 88-RBM7-P1ABX
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ACTN2/7040R |
| Immunogen | Recombinant fragment (aa 557–692) of human ACTN2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | –20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Alpha actinins belong to the spectrin gene superfamily, a diverse group of cytoskeletal proteins including alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in various cell types.
In nonmuscle cells, it is found along microfilament bundles and adherens-type junctions, where it binds actin to the membrane.
In skeletal, cardiac, and smooth muscle cells, alpha actinin isoforms localize to the Z-disc and dense bodies, anchoring myofibrillar actin filaments.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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