Thermo Fisher Scientific SYVN1 Polyclonal Antibody
SYVN1 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot 및 IHC에 사용 가능. Human, Mouse, Rat에 반응. 합성 펩타이드(aa 460–510)로부터 제작. 동결건조 형태, 보존제 없음. 연구용으로만 사용.
- 카탈로그번호
- OSS00400W-100UL
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:2,000 |
| Immunohistochemistry (IHC) | 1:300–1:2,000 |
| Miscellaneous PubMed (Misc) | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 460–510 of mouse SYVN1 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The peptide is homologous in human and rat.
- Specificity of this antibody: SYVN1
Target Information
HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. HRD1 is expressed in many tissues, including brain, pancreas, liver, kidney, and skeletal muscle. Synoviolin/Hrd1 (expressed in rheumatoid synovium) has been reported as a causative factor for arthropathy by triggering synovial cell outgrowth through anti-apoptotic effects. HRD1 contains one ring-type zinc finger.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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