Thermo Fisher Scientific IL-10 Monoclonal Antibody, PeproTech

Applications

Tested Dilution

Publications

Western Blot (WB)

1.0-2.0 µg/mL

-

ELISA (ELISA)

4.0-8.0 µg/mL

-

Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rat

Class

Monoclonal

Type

Antibody

Immunogen

E.coli-derived Recombinant Murine IL-10 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:IL-10,uniProtId:P18893-1,ncbiNodeId:10090,antigenRange:19-178,antigenLength:178,antigenImageFileName:500-M128-500UG_IL-10_P18893-1_Rat.svg,antigenImageFileNamePDP:500-M128-500UG_IL-10_P18893-1_Rat_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

Protein G

Storage buffer

PBS

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

RRID

AB_2942189

Product Specific Information

AA Sequence of recombinant protein: MSRGQYSRED NNCTHFPVGQ SHMLLELRTA FSQVKTFFQT KDQLDNILLT DSLMQDFKGY LGCQALSEMI QFYLVEVMPQ AEKHGPEIKE HLNSLGQKLK TLRMRLRRCH RFLPCENKSK AVEQVKSDFN KLEDQGVYKA MNEFDIFINC IEAYMMIKMK S.

Preparation: Produced in Sprague Dawley rats immunized with highly pure Recombinant Murine IL-10. Anti-Murine IL-10-specific antibody was purified from cell culture by Protein G affinity chromatography.

Target Information

IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.