Thermo Fisher Scientific CD44 Chimeric Recombinant Rabbit Monoclonal Antibody (Hermes -3)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Specificity: This antibody is specific for CD44 (gp90 epitope cluster III). Hermes-3 recognizes Hermes antigen homologues on monkey, goat, and sheep lymphocytes.

Target Information

CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leukocytes, white matter of the brain, and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues.
CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, adhesion, and migration. It plays roles in lymphocyte activation, recirculation, and homing.
CD44 expression may be upregulated in some carcinomas, potentially related to metastatic potential. It is expressed by hematopoietic and non-hematopoietic cells, epithelial tissues, and filopodia in cultured keratinocytes. Bone marrow myeloid cells and memory T cells express CD44 at high levels, and peripheral B and T cells can upregulate CD44 in response to stimulation.
Alternative splicing generates multiple isoforms with distinct functions. Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus, and CD44 may also be related to tumor metastasis formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.