Thermo Fisher Scientific FZD8 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

ELISA

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

• Positive test controls include: 293T, A-549, HeLa, Mouse liver, Rat liver.
• Immunogen sequence:
  PDRMRCDRLP EQGNPDTLCM DYNRTDLTTA APSPPRRLPP PPPGEQPPSG SGHGRPPGAR PPHRGGGRGG GGGDAAAPPA RGGGGGGKAR PPGGGAAPCE PGCQCRAPMV SVSSERHPLY NRVKTGQIAN CALPCHNPFF SQDERA

Target Information

Members of the Frizzled family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway.
Frizzled 8 is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. Its expression has been reported in brain, heart, kidney, pancreas, and skeletal muscle. ESTs have been isolated from embryo, eye, head/neck, heart, kidney, liver/spleen, pancreas, prostate, and testis libraries, as well as many tumor libraries.
The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.