Thermo Fisher Scientific F13A1 Monoclonal Antibody (OTI9E2), TrueMAB
F13A1 단백질을 인식하는 Mouse IgG1 단일클론 항체로, WB, IHC, ICC/IF, Flow 등 다양한 응용에 적합. 고순도 친화 크로마토그래피 정제, PBS/BSA/glycerol 버퍼에 보존. 인간 F13A1 전장 재조합 단백질을 면역원으로 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI9E2 |
| Immunogen | Full length human recombinant protein of human F13A1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats:
- Biotin conjugate available
- Custom conjugation upon request
Target Information
This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits may serve as plasma carrier molecules. Platelet factor XIII consists only of 2 A subunits, identical to those of plasma origin.
Upon cleavage of the activation peptide by thrombin and in the presence of calcium ions, plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor or fibronectin to fibrin alpha chains.
Factor XIII deficiency is classified into:
- Type I deficiency: Lack of both A and B subunits
- Type II deficiency: Lack of A subunit alone
These defects can result in lifelong bleeding tendency, defective wound healing, and habitual abortion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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