Thermo Fisher Scientific Lpin1 protein Polyclonal Antibody
Lpin1 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC, ICC, ELISA 등에 적합합니다. Mouse 및 Rat 시료에 반응하며, Protein A로 정제된 1 mg/mL 액상 형태입니다. 지방 대사 및 인슐린 감수성 연구에 활용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from mouse Lpin1 protein (amino acids 201–300) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The Lipin family of nuclear proteins includes Lipin-1, Lipin-2, and Lipin-3, which share a nuclear signal sequence, an amino-terminal (NLIP) domain, and a carboxy-terminal (CLIP) domain.
LPIN1 (Lipin-1) is essential for normal adipose tissue development and metabolism. It activates pathways related to fatty acid oxidation and mitochondrial oxidative phosphorylation through PPARA, while suppressing lipogenic programs and circulating lipid levels.
LPIN1 abundance is associated with fat accumulation and insulin sensitivity, whereas deficiency can lead to lipodystrophy, fatty liver, and insulin resistance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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