Thermo Fisher Scientific Lpin1 Polyclonal Antibody
LPIN1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, IHC, ICC, ELISA 등 다양한 응용에 적합합니다. 마우스 및 랫트 반응성이 있으며, 고순도 Protein A 정제 및 안정한 글리세롤 기반 완충액에 보관됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from mouse Lpin1 (amino acids 241–340) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01 M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The Lipin family of nuclear proteins includes Lipin-1, Lipin-2, and Lipin-3, all containing a nuclear signal sequence, a conserved NLIP domain, and a CLIP domain. LPIN1 (Lipin-1) is essential for normal adipose tissue development and metabolism. It activates PGC-1α–dependent pathways such as fatty acid oxidation and mitochondrial oxidative phosphorylation through PPARA expression. LPIN1 also suppresses lipogenic programs and reduces circulating lipid levels. Excess LPIN1 promotes fat accumulation and insulin sensitivity, while deficiency can lead to lipodystrophy, fatty liver, and insulin resistance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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