Thermo Fisher Scientific ZCCHC9 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.04–0.4 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:500–1:1,000

Product Specifications

Product Specific Information

Immunogen sequence:
TTYNKRPLPA TSWEDMKKGS FEGTSQNLPK RKQLEANRLS LKNDAPQAKH KKNKKKKEYL NEDVNGFMEY LRQNSQMVHN GQI

Highest antigen sequence identity to the following orthologs:

• Mouse: 73%
• Rat: 72%

Target Information

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass transcriptional activation or repression.
ZCCHC9 (zinc finger, CCHC domain containing 9) is a 271 amino acid protein that contains four CCHC-type zinc fingers, suggesting a role in transcriptional regulation.
The gene encoding ZCCHC9 maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome.
Chromosome 5 is associated with several genetic disorders including Cockayne syndrome (ERCC8 gene), familial adenomatous polyposis (APC gene), Treacher Collins syndrome (TCOF1 gene), and Cri du chat syndrome (deletion of p arm).
Deletion of the q arm or entire chromosome 5 is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.