Thermo Fisher Scientific SUPV3L1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human SUPV3L1. Recombinant protein control fragment (Product #RP-97136). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SUPV3L1,uniProtId:Q8IYB8-1,ncbiNodeId:9606,antigenRange:561-632,antigenLength:786,antigenImageFileName:PA5-58380_SUPV3L1_Q8IYB8-1_Rabbit.svg,antigenImageFileNamePDP:PA5-58380_SUPV3L1_Q8IYB8-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2648090

Product Specific Information

Immunogen sequence: IQHIPLSLRV RYVFCTAPIN KKQPFVCSSL LQFARQYSRN EPLTFAWLRR YIKWPLLPPK NIKDLMDLEA VH

Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.

Target Information

Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3overhang double-stranded RNA with a 3-to-5directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5-to-3` direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA. [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.