Thermo Fisher Scientific CD6 (Negative Marker of T-regulatory Cells) Monoclonal Antibody (3F7B5)
CD6 단백질을 인식하는 마우스 단클론 항체로, T-regulatory 세포의 음성 마커로 활용됩니다. IHC, ICC/IF, Flow Cytometry 등 다양한 응용에 사용 가능하며, 인간 시료에 반응합니다. 단백질 A/G로 정제된 액상 형태로, PBS 완충액에 보존되어 있습니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3F7B5 |
| Immunogen | Human rheumatoid synovial T cell line ST-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD6, also known as T12, is a member of the scavenger receptor superfamily found on T and B cell subsets, thymocytes, and acute lymphocytic leukemia cells (ALL).
It interacts with CD166/ALCAM (activated leukocyte cell adhesion molecule) and serves as a coreceptor for T cell activation and stabilizer of the immunological synapse.
CD6–ALCAM mediated adhesion is important for T cell proliferation and may modulate CD5 signaling.
Ligation of CD6 has an anti-apoptotic role in chronic lymphocytic leukemia B cells.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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