Thermo Fisher Scientific SOCS1 Polyclonal Antibody
SOCS1 단백질을 표적으로 하는 Thermo Fisher Scientific의 폴리클로날 항체로, 인간·마우스·랫트 반응성이 있으며 Western blot에 적합합니다. 항원 친화 크로마토그래피로 정제된 액상 형태이며, 1 mg/mL 농도로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB)
Tested Dilution: 1.0 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 15 amino acid peptide from near the carboxy terminus of human SOCS1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153053 |
Product Specific Information
- A suggested positive control is human spleen tissue lysate.
- PA5-20228 can be used with blocking peptide PEP-0341.
Target Information
The Suppressor of Cytokine Signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins that regulate immune cell responses to cytokines.
SOCS1 suppresses dendritic cell (DC) and T cell hyperactivation by inhibiting JAK tyrosine kinase, essential for cytokine receptor signaling.
It also exhibits E3 ubiquitin ligase activity, mediating polyubiquitination and proteasomal degradation of target proteins.
Through this mechanism, SOCS1 negatively regulates Toll-like receptor (TLR2, TLR4) signaling by degrading the adaptor protein TIRAP.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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