Thermo Fisher Scientific CDK9 Polyclonal Antibody
Rabbit 폴리클로날 항체로 인간 CDK9 단백질을 특이적으로 인식합니다. Western blot, IHC, ELISA, IP 등 다양한 응용에 적합하며 다른 CDK 계열과 교차 반응하지 않습니다. 세포 주기 및 전사 조절 연구용으로 최적화된 연구용 시약입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200–1:1,000 |
| ELISA | 1:10,000–1:50,000 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Multiple synthetic peptides corresponding to the C-terminal and N-terminal domains of human CDK9 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Conditions | 4°C or -20°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_2077305 |
Product Specific Information
PA1-84581 does not cross-react with other cyclin-dependent kinases.
Rabbit anti-human CDK9 antibody recognizes an approximately 43 kDa member of the cyclin-dependent protein kinase (CDK) family, CDK9, previously named PITALRE.
Target Information
CDK9 is a serine/threonine kinase that forms an active holoenzyme complex with Cyclin T1, playing a key role in regulating the eukaryotic cell cycle. CDK9 is coexpressed and copurified with Cyclin T1 and regulates cytokine-inducible transcription networks by facilitating promoter recognition of target transcription factors.
It promotes RNA synthesis in genetic programs for cell growth, differentiation, and viral pathogenesis. The CDK9/cyclin-K complex also has kinase activity toward CTD of RNAPII and can substitute for CDK9/cyclin-T P-TEFb in vitro. Chronic activation of CDK9 causes cardiac myocyte enlargement leading to cardiac hypertrophy and predisposition to heart failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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