Thermo Fisher Scientific KCNIP2 Monoclonal Antibody (OTI2G8), TrueMAB

Applications

• Western Blot (WB): 1:2,000

Product Specifications

Target Information

Voltage-gated potassium (Kv) channels are key components of the potassium currents in the heart and central nervous system. In the heart, Kv4 channels are involved in the repolarization phase of the action potential. In the brain, these channels prevent reverse-propagation of action potentials.

Found associated with Kv4 channels are a group of calcium-binding proteins termed KChIPs (Kv channel interacting proteins). KChIPs are small molecular weight proteins that bind to the cytoplasmic amino termini of Kv4 alpha-subunits and help to modulate their function.
There are currently three known KChIPs:

• KChIP1: expressed in the brain
• KChIP2: expressed in the brain, heart, and lung; has three isoforms (a, b, c)
• KChIP3: also known as calsenilin and DREAM, expressed in the brain and testis

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.