Thermo Fisher Scientific PON3 Monoclonal Antibody (OTI4H9), TrueMAB
Thermo Fisher Scientific의 PON3 단클론 항체(OTI4H9)는 인간 PON3 단백질(aa 30-319)을 항원으로 제작된 Mouse IgG1 항체입니다. Western blot에 적합하며, 고순도 Affinity chromatography로 정제되었습니다. 연구용으로만 사용됩니다.
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Applications
- Western Blot (WB): Tested dilution 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4H9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 30–319 of human PON3 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Paraoxonase-1 (PON1) is a calcium-dependent ester hydrolase associated with apoA-I in HDL. PON1 prevents LDL oxidation and atherogenic oxidised-LDL formation. Human PON1 polymorphisms are linked to coronary artery disease. PON1 activity is lower in individuals prone to atherosclerosis, such as those with diabetes, hypercholesterolemia, or renal disease. PON2 is an intracellular protein protecting cells from oxidative damage. PON3 is similar to PON1 but differs in substrate specificity. Both PON1 and PON3 are implicated in reducing coronary artery disease risk. Human PON3 shares three conserved cysteine residues with PON1, suggesting their importance in vivo. PON1-based catalytic scavengers may serve as safe and effective agents against organophosphate intoxication.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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