Thermo Fisher Scientific CDKL2 Monoclonal Antibody (OTI1D1), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).

Target Information

Activation of signal transduction pathways by growth factors, hormones, and neurotransmitters is mediated by MAP kinases ERK1 and ERK2.
ERK proteins are regulated by dual phosphorylation at specific tyrosine and threonine sites within the Thr-Glu-Tyr motif.
The protein kinase p56 KKIAMRE, distantly related to MAP kinases and closely related to p42 KKIALRE, is predominantly expressed in testis, kidney, brain, and lung.
KKIAMRE contains the conserved MAP kinase dual phosphorylation motif (Thr-Asp-Tyr) and is activated by EGF treatment.
Unlike other MAP kinases, EGF-stimulated kinase activity does not require phosphorylation in the Thr-Asp-Tyr motif.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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