Thermo Fisher Scientific N-Cadherin/Cadherin-2/CD325 (NCAD) Monoclonal Antibody (CDH2/1573)
N-Cadherin(CDH2) 단백질을 표적하는 Mouse Monoclonal Antibody로, 인간 및 마우스 시료에 반응합니다. IHC(P) 및 IHC(PFA) 실험에 사용 가능하며, Protein A/G로 정제된 액상 형태입니다. 세포 간 접착 및 형태 형성 연구에 적합합니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CDH2/1573 |
| Immunogen | Recombinant human CDH2 intracellular domain |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
N-cadherin is a 140 kDa transmembrane protein belonging to the cadherin family, which mediates calcium-dependent intercellular adhesion. Cadherins regulate morphogenetic movements during development and control cell surface adhesion through homotypic interactions with the same cadherin species.
N-cadherin’s function depends on its association with the actin cytoskeleton via interactions between its C-terminal region and cytoplasmic catenin proteins. This association is regulated by phosphorylation and dephosphorylation of beta-catenin.
N-cadherin is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a conserved cytoplasmic tail. It plays an essential role during gastrulation and in establishing left-right asymmetry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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