Thermo Fisher Scientific N-Cadherin/Cadherin-2/CD325 (NCAD) Monoclonal Antibody (rCDH2/1426)
인간 N-Cadherin(CDH2)을 인식하는 Mouse monoclonal antibody로, IHC(P) 및 IHC(PFA)에 적합. 액상 형태로 제공되며, 1 mg/mL 농도, PBS(pH 7.4) buffer에 보존제 없음. 세포 간 접착 및 발달 과정 연구용으로 적합.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | rCDH2/1426 |
| Immunogen | Recombinant full-length human CDH2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
N-cadherin is a 140 kDa transmembrane protein that mediates calcium-dependent intercellular adhesion. It plays a critical role in morphogenetic movements during development and regulates cell surface adhesion through homotypic interactions.
Its function depends on association with the actin cytoskeleton via interactions between the C-terminal region of N-cadherin and cytoplasmic catenin proteins. The stability of this association is controlled by phosphorylation and dephosphorylation of beta-catenin.
N-cadherin is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a conserved cytoplasmic tail. It is essential during gastrulation and for establishing left-right asymmetry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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