Thermo Fisher Scientific NOP, Nociceptin/Orphanin FQ Receptor Polyclonal Antibody
Rabbit polyclonal antibody targeting human NOP receptor for WB applications. Recognizes human, mouse, and rat samples. High purity via antigen affinity chromatography. Provided in liquid form with 1 mg/mL concentration. Ideal for GPCR and nociception r...
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Applications
- Western Blot (WB)
Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide representing the carboxyl-terminal tail of human NOP (OPRL1, UniProt ID: P41146-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.4 |
| Contains | 0.02% Sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
The G-protein-coupled receptor (GPCR) superfamily comprises approximately 600–1,000 members and represents the largest known class of molecular targets with therapeutic potential.
The nociceptin receptor (NOP) is a G-protein-coupled opioid receptor that binds the endogenous neuropeptide nociceptin. Ligand binding induces conformational changes that activate guanine nucleotide-binding proteins (G proteins), modulating downstream effectors such as adenylate cyclase and calcium channels.
Arrestins further regulate G protein signaling and activate alternative pathways leading to MAP kinase activation.
NOP plays a key role in modulating nociception, pain perception, and locomotor activity regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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