Thermo Fisher Scientific CTDSP1 Polyclonal Antibody
CTDSP1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간 시료에 반응하며, ICC/IF 실험에 적합. 고순도 항원 친화 크로마토그래피 정제, 액상 형태로 제공. 연구용으로만 사용 가능.
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Applications
- Immunocytochemistry (ICC/IF): 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human CTDSP1. Recombinant protein control fragment (Product #RP-107181) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2664709 |
Product Specific Information
- Immunogen sequence: EALPAHSGAPL LVEENGAIPK QTPVQYLLPE AKAQDSDKIC VV
- Highest antigen sequence identity to orthologs: mouse 95%, rat 93%
Target Information
CTDSP1 is a class 2C phosphatase with activity dependent on the conserved DxD motif. Expression of CTDSP1 inhibits activated transcription from several promoter-reporter gene constructs, while a mutant lacking phosphatase activity enhances transcription.
Neuronal gene transcription is repressed in nonneuronal cells by the REST/NRSF complex, which recruits SCPs to neuronal genes containing RE1 elements, leading to silencing. Phosphatase-inactive SCP forms interfere with REST/NRSF function and promote neuronal differentiation. SCP activity acts as an evolutionarily conserved transcriptional regulator that globally silences neuronal genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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