Thermo Fisher Scientific Phospho-JAK3 (Tyr981) Polyclonal Antibody
인간, 마우스, 랫드 등 다양한 종에서 인산화된 Tyr981 위치의 JAK3를 검출하는 폴리클로날 항체. Western blot, IHC, ICC/IF에 사용 가능. 고순도, 1 mg/mL 농도, -20°C 보관. 연구용으로만 사용.
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- PA5105892
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Thermo Fisher Scientific Phospho-JAK3 (Tyr981) Polyclonal Antibody
Applications and Tested Dilutions
- Western Blot (WB): 1:1,000–1:3,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
- Immunocytochemistry (ICC/IF): 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human JAK3 (Accession P52333), corresponding to amino acid residues around phosphorylated Tyr981 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2817291 |
Product Specific Information
This antibody detects endogenous levels of JAK3 only when phosphorylated at Tyr981.
Target Information
Janus kinase 3 (JAK3) phosphorylates members of the STAT (signal transduction and activators of transcription) family.
JAK3 is predominantly expressed in immune cells and mediates signaling in response to interleukin receptor activation.
Upon cytokine or interferon stimulation, JAKs are activated via phosphorylation at adjacent tyrosine residues, leading to STAT activation, dimerization, and nuclear translocation.
Activated STAT proteins regulate transcription of various genes, including interferon-stimulated genes.
JAK2 is essential for IFN gamma-receptor complex initiation, while JAK1 acts as an amplifier.
Some studies suggest that Tyk2 and JAK3 may substitute for JAK2 under certain conditions within the IFN gamma-receptor complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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