Thermo Fisher Scientific PD-1 (CD279) Chimeric Recombinant Rabbit Monoclonal Antibody (RMP1-14)
마우스 PD-1에 특이적으로 결합하는 재조합 래빗 모노클로날 항체. IHC, ICC, Flow Cytometry, Inhibition Assay 등 다양한 면역 분석에 사용 가능. 고순도 Protein A 정제, 1 mg/mL 농도, 장기 보관 시 -20°C 권장.
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Thermo Fisher Scientific PD-1 (CD279) Chimeric Recombinant Rabbit Monoclonal Antibody (RMP1-14)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 1 µg/mL |
| Inhibition Assays (IA) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | RMP1-14 |
| Immunogen | The original rat hybridoma was generated by immunizing Sprague Dawley rats with mouse PD-1-transfected BHK cells. A P3U1 myeloma was used as the fusion partner. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074526 |
Product Specific Information
Specificity: This antibody binds to murine PD-1.
Target Information
Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC).
T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC.
PD-1 binds two related ligands, PDL-1 and PDL-2. Upon binding, PD-1 transmits inhibitory signals that suppress immune activation in the absence of danger signals such as LPS or other pathogen-associated molecules.
PD-1 deficient mice exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at a higher molecular weight in SDS-PAGE.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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