Thermo Fisher Scientific PD-1 (CD279) Chimeric Recombinant Rabbit Monoclonal Antibody (RMP1-14)

Thermo Fisher Scientific PD-1 (CD279) Chimeric Recombinant Rabbit Monoclonal Antibody (RMP1-14)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Specificity: This antibody binds to murine PD-1.

Target Information

Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC).
T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC.
PD-1 binds two related ligands, PDL-1 and PDL-2. Upon binding, PD-1 transmits inhibitory signals that suppress immune activation in the absence of danger signals such as LPS or other pathogen-associated molecules.
PD-1 deficient mice exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at a higher molecular weight in SDS-PAGE.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.