Thermo Fisher Scientific CD29 (Integrin beta 1) Monoclonal Antibody (eBioHMb1-1 (HMb1-1)), APC, eBioscience
마우스와 랫트 CD29(Integrin β1)을 인식하는 단일클론 항체로, APC로 결합되어 유세포분석에 적합합니다. 0.25 µg/test 농도로 사용 가능하며, 651/660 nm 파장에서 여기/방출됩니다. 세포 부착, 이동, 분화 연구에 활용됩니다.
- 카탈로그번호
- 17-0291-8x (2개 옵션)
- 판매단위
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2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD29 (Integrin beta 1) Monoclonal Antibody (eBioHMb1-1 (HMb1-1)), APC, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| Flow Cytometry (Flow) | 0.25 µg/test | View 78 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Armenian hamster / IgG |
| Recommended Isotype Control | Armenian Hamster IgG Isotype Control (eBio299Arm), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBioHMb1-1 (HMb1-1) |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1210794 |
Additional Formats Available
- Unconjugated
- APC-eFluor 780
- Biotin
- eFluor 450
- FITC
- Functional Grade
- NovaFluor Blue 660-120S
- NovaFluor Red 685
- NovaFluor Red 700
- NovaFluor Red 755
- NovaFluor Yellow 660
- NovaFluor Yellow 700
- PE
- PE-Cyanine7
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Super Bright 702
- Request custom conjugation
Product Specific Information
Description:
The eBioHMb1-1 monoclonal antibody reacts with mouse and rat CD29 (integrin beta 1), a 110–120 kDa member of the beta integrin family expressed by leukocytes, endothelial, smooth muscle, and epithelial cells. CD29 binds non-covalently with alpha integrins (CD49a–f) to form VLA-1 through VLA-6 complexes, as well as with CD51. These heterodimers mediate cellular adhesion, trafficking, proliferation, and differentiation. CD29-containing integrins bind to extracellular matrix proteins such as collagen, laminin, fibronectin, and vitronectin, and also interact with cellular receptors like VCAM-1 and MadCAM-1.
Applications Reported:
This antibody is reported for use in flow cytometric analysis.
Applications Tested:
Tested by flow cytometric analysis of mouse bone marrow cells. Recommended ≤0.25 µg/test (100 µL final volume). Cell number: 10⁵–10⁸ cells/test. Optimize titration for best performance.
Excitation/Emission: 633–647 nm / 660 nm
Laser: Red Laser
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
Gene: ITGB1 (Integrin Subunit Beta 1, CD29)
Protein Size: 110 kDa cell surface glycoprotein
ITGB1 forms heterodimers with multiple alpha chains (α1–α6), defining VLA integrins that mediate cell adhesion to extracellular matrix proteins. It is expressed in various cell types including leukocytes and platelets. Decreased ITGB1 expression correlates with multidrug resistance in tumor cells. ITGB1 is involved in immune cell trafficking, tissue repair, and inflammatory responses. Two major isoforms, β1A and β1D, show tissue-specific distribution, with β1A in most tissues and β1D in cardiac and skeletal muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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