Thermo Fisher Scientific NAT1 Polyclonal Antibody
NAT1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS 및 글리세롤 버퍼에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (IHC) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length Human NAT1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719749 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
Arylamine N-acetyltransferases (NAT-1 and NAT-2) catalyze N- or O-acetylation of heterocyclic and arylamine substrates involved in the detoxification of various drugs. Certain alleles associated with high N-acetyltransferase activity are linked to colon and urinary bladder cancers, as NATs can bioactivate several known carcinogens. Both NAT-1 and NAT-2 are cytoplasmic proteins that play a role in detoxifying arylamine and hydrazine drugs. N-acetylation polymorphism, determined by NAT activity levels in liver tissues, affects drug action and toxicity. Human NAT-1 is the functional homolog of rodent NAT-2, while human NAT-2 corresponds functionally to rodent NAT-1.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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