Thermo Fisher Scientific FXIIIA Polyclonal Antibody, FITC
FXIIIA 단백질을 표적으로 하는 FITC 결합 폴리클로날 항체로, Western blot, ELISA, IP 등에 사용 가능. 고순도 친화 크로마토그래피 정제, 498/517 nm 형광 특성. 인체, 고양이, 생쥐, 영장류 반응성. 연구용으로만 사용.
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Thermo Fisher Scientific FXIIIA Polyclonal Antibody, FITC
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Cat, Human, Mouse, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 1–50 on human factor XIII A subunit protein |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The FXIIIA gene encodes the coagulation factor XIII A subunit, the final zymogen activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of two A subunits (catalytic) and two B subunits (carrier). Platelet factor XIII consists of two A subunits identical to plasma origin. Upon thrombin cleavage and calcium ion presence, plasma factor XIII releases B subunits, forming active factor XIIIa. This enzyme catalyzes gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, stabilizing clots, and also crosslinks alpha-2-plasmin inhibitor or fibronectin to fibrin alpha chains. Factor XIII deficiency types:
- Type I: Lack of both A and B subunits
- Type II: Lack of A subunit only
Deficiency leads to bleeding tendency, poor wound healing, and habitual abortion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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