Thermo Fisher Scientific Human EBI3 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 15 amino acids near the carboxy terminus of human EBI3.
PEP-0782 can be used as a blocking peptide with polyclonal antibody PA5-20662.

Target Information

EBI3 (Epstein-Barr virus Induced-3) is a secreted glycoprotein of the hematopoietin receptor family. It plays a critical regulatory role in the induction of Th2-type immune responses and the development of Th2-mediated tissue inflammation in vivo, which may be mediated through the control of iNKT cell function.

EBI3 dimerizes with p28 and p35 subunits of IL-12 to form new proteins IL-27 and IL-35, respectively. IL-27 is an early product of activated antigen presenting cells produced upon TLR ligation and negatively regulates Th17 cell differentiation.

EBI3 is widely expressed, and its expression in dendritic cells is transcriptionally regulated by TLR signaling via MyD88 and NF-kappaB during innate immune responses preceding cytokine-driven Th cell development.

EBI3 signaling inhibits delayed-type hypersensitivity responses by suppressing IL-17 production and inducing IL-10 hyperproduction. It may also play a novel role in controlling tumor metastasis via lung CD8+ T cells, and its deficiency is associated with diminished Th2 cytokine production, which regulates allergic airway inflammation in asthma. Targeted deletion of EBI3 protects mice from lung metastasis.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.