Thermo Fisher Scientific Human GLE1 Synthetic Peptide
인간 GLE1 단백질의 C-말단 14개 아미노산 서열에 해당하는 합성 펩타이드. 항체 PA5-20660의 블로킹 펩타이드로 사용 가능. mRNA 수출 연구 및 Gle1 단백질 기능 분석에 적합. 연구용으로만 사용.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 14 amino acids near the carboxy terminus of human Gle1.
PEP-0780 can be used as a blocking peptide with polyclonal antibody PA5-20660.
Target Information
The proper expression of gene products in eukaryotic cells relies on efficient transport of mRNA molecules out of the nucleus. Gle1 is an essential mRNA export factor in both human and yeast cells. It associates with the nuclear pore complex (NPC) through hCG1 and NUP155 in mammalian cells and, in conjunction with inositol hexakisphosphate (IP6), stimulates Dbp5, a member of the DEAD-box helicase family, triggering mRNP remodeling and facilitating RNA export from the nucleus.
Recent evidence suggests that mutations in Gle1 causing defects in mRNA export can result in human disease. At least three isoforms of Gle1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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