Thermo Fisher Scientific Human GLE1 Synthetic Peptide
인간 Gle1 단백질의 중간 영역 15개 아미노산 서열을 기반으로 한 합성 펩타이드. 폴리클로날 항체 PA5-20661의 블로킹 펩타이드로 사용 가능. 액상 형태로 제공되며, PBS 버퍼에 BSA와 sodium azide 포함. 연구용으로만 사용 가능.
- 카탈로그번호
- PEP0781
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Human GLE1 Synthetic Peptide
Applications
- Control (Ctrl): Assay-dependent
- Blocking Assay (BLOCK): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 15 amino acids near the middle of human Gle1.
PEP-0781 can be used as a blocking peptide with polyclonal antibody PA5-20661.
Target Information
The proper expression of gene products in eukaryotic cells relies on efficient transport of mRNA molecules out of the nucleus. Gle1 is an essential mRNA export factor in both human and yeast cells. It associates with the nuclear pore complex (NPC) through hCG1 and NUP155 in mammalian cells and, in conjunction with inositol hexakisphosphate (IP6), stimulates Dbp5, a member of the DEAD-box helicase family, triggering mRNP remodeling and facilitating RNA export from the nucleus.
Recent evidence suggests that mutations in Gle1 causing defects in mRNA export can result in human disease. At least three isoforms of Gle1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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