Thermo Fisher Scientific GATA3 Monoclonal Antibody (KT122)

Thermo Fisher Scientific GATA3 Monoclonal Antibody (KT122)

Applications

• Western Blot (WB): Tested dilution 1:1,000
• Indirect ELISA (reported use)

Product Specifications

Product Specific Information

This product was used in an Indirect ELISA.

Target Information

The genes for all four subunits of the T-cell antigen receptor (alpha, beta, gamma, and delta) are controlled by distinct enhancers and their enhancer-binding proteins. Marine and Winoto (1991) identified a common TCR regulatory element by demonstrating binding of the enhancer-binding protein GATA3 to the enhancer elements of all four TCR genes.
GATA3, containing a zinc finger domain, is abundantly expressed in the T-lymphocyte lineage and participates in T-cell receptor gene activation through enhancer binding.
Labastie et al. (1994) cloned the human gene and the 5′ end of the mouse gene, showing conservation in zinc finger domains with GATA1.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.