Thermo Fisher Scientific CTCF Monoclonal Antibody (KT70)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This product was used in an Indirect ELISA.

Target Information

Transcriptional factor CTCF is a ubiquitously expressed 11-zinc finger domain-containing, DNA-binding nuclear phosphoprotein involved in multiple aspects of gene regulation, including transcriptional repression and activation, gene silencing, chromatin insulation, and regulation of imprinted sites.
CTCF interacts with the CCCTC motif on DNA using different combinations of zinc finger domains and can associate with HAT- and HDAC-containing complexes, influencing transcriptional activation or repression.
It plays roles in transactivation of the APPB gene, silencing of the c-myc gene, insulation of the human beta-globin and DMI myotonic dystrophy loci, and imprinting control of IGF2 and H19 regions.
CTCF also regulates Pax6 and IRAK2 promoter transcription, offering potential therapeutic implications.
Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.