Thermo Fisher Scientific ADAR1 Polyclonal Antibody

Thermo Fisher Scientific ADAR1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

Adenosine Deaminase RNA Specific (ADAR) catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA), referred to as A-to-I RNA editing. This process can influence gene expression and function in various ways, including:

• Altering mRNA translation by changing codons and amino acid sequences
• Modifying pre-mRNA splicing by altering splice site recognition
• Affecting RNA stability and genetic stability of viral genomes
• Influencing microRNA production, targeting, and protein-RNA interactions

ADAR can edit both viral and cellular RNAs, either at multiple sites (hyper-editing) or specific sites (site-specific editing). Known cellular RNA substrates include BLCAP, GRIA2, HTR2C, and GABRA3, with site-specific editing leading to amino acid substitutions that alter protein function.

Viral RNA substrates include HCV, VSV, MV, HDV, and HIV-1, where ADAR exhibits proviral or antiviral effects depending on the virus and mechanism. For example:

• Inhibits HCV replication via RNA editing
• Enhances MV, VSV, and HIV-1 replication through editing-independent mechanisms
• Stimulates HIV-1 infectivity via editing of viral RNAs
• Modulates HDV replication through A-to-I editing of amber/W codon

High levels of ADAR1 can inhibit HDV replication.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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