Thermo Fisher Scientific ADAR1 Polyclonal Antibody
Thermo Fisher Scientific의 ADAR1 Polyclonal Antibody는 인간 ADAR1 단백질을 인식하는 고품질 항체로, WB, IHC, ICC, ELISA 등 다양한 응용에 적합합니다. Protein A로 정제된 액상 형태이며, 안정적인 저장 및 높은 특이성을 제공합니다.
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Thermo Fisher Scientific ADAR1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human ADAR1 (amino acids 151–250) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS (pH 7.4), 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Adenosine Deaminase RNA Specific (ADAR) catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA), known as A-to-I RNA editing.
This process can alter gene expression and protein function through changes in:
- mRNA translation (codon modification)
- pre-mRNA splicing
- RNA stability and nuclease recognition
- RNA virus genome replication
- microRNA processing and protein-RNA interactions
ADAR1 edits both viral and cellular RNAs, acting in either proviral or antiviral roles depending on the virus type.
Notable substrates include BLCAP, GRIA2, HTR2C, and GABRA3, where site-specific editing leads to amino acid substitutions and functional modulation.
ADAR1 influences replication of viruses such as HCV, VSV, MV, HDV, and HIV-1, with editing-dependent and editing-independent effects.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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