Thermo Fisher Scientific IL-29 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• In direct ELISAs and Western blots, approximately 25% cross-reactivity with recombinant human IL-28A and IL-28B is observed.
• Reconstitute at 0.2 mg/mL in sterile PBS.
• Endotoxin level is <0.10 EU per 1 µg of antibody by the LAL method.

Target Information

IFN-lambdas constitute a novel family of interferons that mediate the induction of antiviral protection in a wide variety of cells.
There are three members in this family — lambda1, lambda2, and lambda3 — also known as IL-29, IL-28A, and IL-28B, respectively.
Similar to type I interferons, IFN-lambdas activate intracellular signaling to promote gene expression.

IFN-lambdas mediate antiviral protection through a class II cytokine receptor complex composed of two essential receptor proteins:

• CRF2-12/IFN-lambdaR1: unique to IFN-lambdas
• CFR2-4/IL-10R2: shared with IL-10, IL-22, and IL-26 receptors

IL-28 and IL-29 have been reported to prime dendritic cells to induce proliferation of Foxp3-bearing regulatory T cells.
Dendritic cells differentiated in response to IFN-lambdas express high levels of MHC class I and II, but low levels of costimulatory molecules, and can specifically induce IL-2-dependent proliferation of CD4⁺CD25⁺FOXP3⁺ T cells with contact-dependent suppressive activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.