Thermo Fisher Scientific Beta-2 Microglobulin (Renal Failure and Tumor Marker) Recombinant Rabbit Monoclonal Antibody (B2M/7013R)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: Assay-dependent

Immunohistochemistry (PFA fixed) (IHC (PFA))

• Tested Dilution: 1–2 µg/mL

Product Specifications

Target Information

Beta-2-microglobulin (B2M) is a 12–14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I. Human beta 2 microglobulin associated with HLA Class I antigens is expressed on many cell types including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes. It is also found in free form in plasma.

The amino acid sequence of Beta-2-microglobulin is homologous to the constant regions of immunoglobulin heavy and light chains, with a predominantly beta-pleated sheet structure. The protein is ubiquitously expressed in the cytoplasm and involved in antigen processing and presentation. Beta-2-microglobulin also plays a role in TCR signaling and downstream signaling in naive CD8+ cells.

The B2M gene is located on chromosome 15. Mutations in this gene can result in hypercatabolic hypoproteinemia. Beta-2-microglobulin levels can be used to assess renal function in kidney transplant recipients and serve as a prognostic marker for HIV infection.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.