Thermo Fisher Scientific Beta-2 Microglobulin (Renal Failure and Tumor Marker) Recombinant Rabbit Monoclonal Antibody (B2M/7013R)
인체 및 비인체 영장류 반응성의 재조합 토끼 단클론 항체로, Beta-2 Microglobulin을 표적합니다. IHC(P) 및 IHC(PFA) 실험에 적합하며, 단백질 A로 정제된 액상 형태입니다. 신장 기능 및 종양 마커 연구용으로 사용됩니다.
- 카탈로그번호
- 567-RBM8-P1ABX
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | B2M/7013R |
| Immunogen | Recombinant full-length human B2M protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Beta-2-microglobulin (B2M) is a 12–14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I. Human beta 2 microglobulin associated with HLA Class I antigens is expressed on many cell types including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes. It is also found in free form in plasma.
The amino acid sequence of Beta-2-microglobulin is homologous to the constant regions of immunoglobulin heavy and light chains, with a predominantly beta-pleated sheet structure. The protein is ubiquitously expressed in the cytoplasm and involved in antigen processing and presentation. Beta-2-microglobulin also plays a role in TCR signaling and downstream signaling in naive CD8+ cells.
The B2M gene is located on chromosome 15. Mutations in this gene can result in hypercatabolic hypoproteinemia. Beta-2-microglobulin levels can be used to assess renal function in kidney transplant recipients and serve as a prognostic marker for HIV infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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