Thermo Fisher Scientific TIM-1 Recombinant Rabbit Monoclonal Antibody (9E1)

Thermo Fisher Scientific TIM-1 Recombinant Rabbit Monoclonal Antibody (9E1)

Applications and Tested Dilution

• Western Blot (WB): 1:500–1:5,000
• ELISA: Assay-dependent

Product Specifications

Target Information

CD365, also known as T-cell immunoglobulin and mucin domain 1 (Tim-1), is a type I surface glycoprotein with an extracellular N-terminal immunoglobulin V-like domain, a mucin domain, and a short cytoplasmic tail.
Its endogenous ligand is Tim-4. CD365 acts as a cellular receptor or co-receptor for several viruses, including hepatitis A and C, Ebola, Marburg, Dengue, Zika, West Nile, and Japanese encephalitis viruses.
Binding occurs via phosphatidylserine exposed on viral envelopes. Polymorphisms in the human CD365 gene (HAVCR1) are associated with infection susceptibility and disease severity.
CD365 also plays a role in T cell co-stimulation and is primarily expressed in epithelial cells, notably in A549, 769-P, and Caco-2 cell lines. A soluble form of CD365 can be generated by metalloproteinase-mediated cleavage.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.