Thermo Fisher Scientific Insulin Receptor (IR) Monoclonal Antibody (ABM258)
인슐린 수용체(Insulin Receptor, IR)를 검출하기 위한 Mouse Monoclonal Antibody. Western blot 및 IHC(Paraffin) 실험에 적합. Human 시료 반응성, 단일클론, Protein A 정제, 액상 형태로 제공. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ABM258 |
| Immunogen | Highly purified human placental Insulin Receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Human placenta and IM-9 cells
- Cellular location: Membrane
Target Information
INSR (Insulin Receptor) is a receptor tyrosine kinase. Binding of insulin to the extracellular domain of INSR stimulates glucose uptake. INSR and IGF-1 receptors share major structural and functional similarity. The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine in INSR. In humans, the INSR gene is located on chromosome 19. Defects in INSR are associated with various insulin resistance syndromes, and IGF-1R defects may also cause growth retardation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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