Thermo Fisher Scientific WT1-AS Polyclonal Antibody
WT1-AS 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체. Western blot에 적합하며 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 고순도(>95%) 제품. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues in Human WT1-AS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719318 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is >95% (by SDS-PAGE).
Target Information
Wilms' tumor is a neoplasm of the kidneys that usually occurs in children and is characterized by abortive tubules and glomeruli surrounded by a spindled cell stroma.
The 11p13 Wilms' tumor locus consists of two coordinately regulated transcripts, WT1 and WIT-1, which are mutated in Wilms' tumors.
Wilms' tumor upstream neighbor 1 (WIT-1) is encoded by an intron-less gene upstream of the WT1 gene, important for nephrogenesis and gonadal growth.
The WT1 gene is bi-directionally transcribed from the same promoter region as WIT-1, which may function as an antisense regulator of WT1.
Both genes have similar temporal and cell-restricted expression patterns, although WIT-1 expression is less abundant.
Methylation of the WIT-1 gene is implicated in hematologic malignancy of chemoresistant acute myeloid leukemia.
Single nucleotide polymorphisms (SNPs) in the WIT-1 gene are associated with focal segmental glomerulosclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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