Thermo Fisher Scientific IFITM3 Monoclonal Antibody (4C8-1B10)
인간 IFITM3 단백질을 표적으로 하는 Mouse IgG1 단일클론 항체. Western blot 및 ELISA에 적합하며, 고순도 친화성 크로마토그래피로 정제됨. PBS(pH 7.4) 용액 형태로 제공되며, -20°C에서 보관 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 0.3 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4C8-1B10 |
| Immunogen | IFITM3 (AAH06794, 1–133 a.a) full-length recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of IFITM3 protein:
MNHTVQTFFS PVNSGQPPNY EMLKEEHEVA VLGAPHNPAP PTSTVIHIRS ETSVPDHVVW SLFNTLFMNP CCLGFIAFAY SVKSRDRKMV GDVTGAQAYA STAKCLNIWA LILGILMTIL LIVIPVLIFQ AYGTarget Information
IFITM3 (interferon induced transmembrane protein 3), also known as 1-8U or IP15, is a multi-pass membrane protein belonging to the IFITM family. These proteins are induced by type I and II interferons and contain multiple interferon-stimulated response elements (ISREs) in their promoter regions.
IFITM proteins play roles in:
- Cellular anti-proliferative activities
- Homotypic cell adhesion functions of interferons
- Regulation by chromatin remodeling complexes (SWI/SNF-like BAF)
IFITM genes are often upregulated in cancer cells, suggesting involvement in carcinogenesis. IFITM3 is a 133 amino acid membrane protein induced by IFN-α and IFN-γ, and its expression is regulated by TEF-1, Brg-1, and Sp1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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