Thermo Fisher Scientific CD8 Monoclonal Antibody (LT8), PE

Applications

• Flow Cytometry (Flow)

Tested Dilution: Neat
Publications: -

Product Specifications

Product Specific Information

• Reconstitute with 1 mL of distilled water.
• After reconstitution, store product undiluted at 4ºC in the dark.
• For FACS analysis, use 10 µL of the suggested working dilution to label 1×10^6 cells in 100 µL.

Target Information

Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin family that plays a key role in T cell signal transduction, differentiation, and activation.
CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with the T cell receptor (TCR) for MHC class I molecules.
It is also found on subsets of T cells, NK cells, monocytes, and dendritic cells as homodimers of CD8α.
Binding of MHC-I/peptide complexes triggers recruitment of Lck kinase, leading to cytokine production, motility, and cytotoxic T lymphocyte (CTL) activation.
Activated CTLs are essential for pathogen and tumor cell clearance.
Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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