Thermo Fisher Scientific ABCB1 Monoclonal Antibody (OTI11D2), TrueMAB
Human ABCB1 단백질을 인식하는 단일클론 항체로, IHC(P)에서 1:150 희석으로 사용 가능. 비결합형, 동결건조 형태로 제공되며, 친화 크로마토그래피로 정제됨. 약물 내성 연구 및 ABC 수송체 연구에 적합.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI11D2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 995–1280 of human ABCB1 produced in SF9 cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
The membrane-associated protein encoded by the ABCB1 gene belongs to the ATP-binding cassette (ABC) transporter superfamily. These proteins transport various molecules across cellular membranes and are divided into seven subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
ABCB1 is part of the MDR/TAP subfamily, involved in multidrug resistance. It functions as an ATP-dependent efflux pump for xenobiotic compounds, reducing intracellular drug accumulation and contributing to anticancer drug resistance. Additionally, ABCB1 acts as a transporter in the blood-brain barrier.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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