Thermo Fisher Scientific ABCB1 Monoclonal Antibody (OTI1A7), TrueMAB
인간 ABCB1 단백질을 인식하는 단클론 항체로, IHC(P)에서 1:150 희석으로 사용 가능. 무보존제 동결건조 형태이며, 재구성 후 약 1 mg/mL 농도로 사용. 다약제 내성 연구 및 P-glycoprotein 분석에 적합.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1A7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 995–1280 of human ABCB1 produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, it is recommended to perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
The membrane-associated protein encoded by this gene belongs to the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across cellular membranes and are classified into seven subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
This protein is part of the MDR/TAP subfamily, which is involved in multidrug resistance. It functions as an ATP-dependent drug efflux pump with broad substrate specificity, reducing drug accumulation in multidrug-resistant cells and contributing to anticancer drug resistance. Additionally, it acts as a transporter in the blood-brain barrier.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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