Thermo Fisher Scientific HP1 alpha Recombinant Rabbit Monoclonal Antibody (ARC0244)
HP1 alpha 단백질을 인식하는 재조합 토끼 단클론 항체 ARC0244. Western blot, IHC, ICC/IF, ELISA, IP 등 다양한 응용에 적합. Human, Mouse, Rat 반응성. 높은 순도와 안정성, 연구용으로 최적화된 항체.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific HP1 alpha Recombinant Rabbit Monoclonal Antibody (ARC0244)
Thermo Fisher Scientific HP1 alpha Recombinant Rabbit Monoclonal Antibody (ARC0244)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:4,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:200–1:800 |
| ELISA | 1 µg/mL |
| Immunoprecipitation (IP) | 0.5–4 µg antibody for 200–400 µg extracts |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC0244 |
| Immunogen | Synthetic peptide corresponding to amino acids 92–191 of human HP1 alpha/CBX5 (P45973) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.64 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849298 |
Product Specific Information
Immunogen sequence:
SNFSNSADDI KSKKKREQSN DIARGFERGL EPEKIIGATD SCGDLMFLMK WKDTDEADLV LAKEANVKCP QIVIAFYEER LTWHAYPEDA ENKEKETAKS
Target Information
Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, mediating gene silencing. Mammalian methyltransferases that selectively methylate histone H3 on lysine-9 generate a binding site for HP1 proteins, a family of adaptor molecules involved in gene silencing and chromatin structure. High-affinity recognition of methylated histone H3 peptide by HP1 requires a functional chromodomain, which serves as a specific interaction motif for the methyl epitope on lysine-9 of histone H3. In vivo, heterochromatin association of HP1 proteins is lost in Suv39h double-knockout mouse fibroblasts but restored after reintroduction of catalytically active SUV39H1 HMTase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 없음)
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.