Thermo Fisher Scientific CATSPER1 Polyclonal Antibody
CATSPER1 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot 및 IHC에 사용 가능. 마우스 시료에 반응하며, 동결건조 형태로 제공. 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:200–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:200–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 2–50 of mouse CATSPER1 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: CATSPER1.
Target Information
CATSPER1 is a voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction, and chemotaxis towards the oocyte.
It is activated by extracellular progesterone and prostaglandins in the following order of potency: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2.
Progesterone activation shifts voltage dependence towards more physiological, negative membrane potentials and is not mediated by metabotropic receptors or second messengers.
Sperm capacitation enhances the effect of progesterone by providing an additional negative shift. Also activated by elevated intracellular pH.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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