Thermo Fisher Scientific CTCF Monoclonal Antibody (CL0305)
CTCF 단백질을 인식하는 Mouse monoclonal 항체(CL0305)로, Western blot, IHC, ICC/IF 등 다양한 응용에 적합합니다. Human 시료에 반응하며 Protein A로 정제된 액상 형태입니다. 4°C 단기, -20°C 장기 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CL0305 |
| Immunogen | Recombinant protein corresponding to Human CTCF (amino acids 42–189) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2786981 |
Product Specific Information
Immunogen sequence:
QNQTDGGEVV QDVNSSVQMV MMEQLDPTLL QMKTEVMEGT VAPEAEAAVD DTQIITLQVV NMEEQPINIG ELQLVQVPVP VTVPVATTSV EELQGAYENE VSKEGLAESE PMICHTLPLP EGFQVVKVGA NGEVETLEQG ELPPQEDP
Target Information
Transcriptional factor CTCF is a ubiquitously expressed 11-zinc finger domain-containing, DNA-binding nuclear phosphoprotein involved in multiple aspects of gene regulation, including transcriptional repression and activation, gene silencing, chromatin insulation, and regulation of imprinted sites.
CTCF interacts with the CCCTC DNA motif and can bind to HAT- and HDAC-containing complexes, influencing transcriptional activation or repression.
It plays roles in transactivation of the APPB gene, silencing of the c-myc gene, insulation of the human beta-globin and DMI myotonic dystrophy loci, and imprinting control of IGF2 and H19 regions.
Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms’ tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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